SDSU2022NICE - Scientific Workshop "Sound, Neuroscience & Cognition"

Objectifs de la Semaine du Son de l'UNESCO NICE :Susciter des recherches médicales, scientifiques et sociétales sur le Son et la Santé par des actions de conférences, ateliers et représentations artistiques pendant une semaine.Il s’agit de générer des rencontres autour de l’impact du son dans sa globalité (bruit et musique) sur l’homme et sa santé auditive et mentale, sa qualité de vie, ainsi que ses relations avec les sens visuel (photo, cinéma) et olfactif.Ces rencontres sont articulées- en premier lieu, autour de conférences scientifiques centrées sur l’impact du son sur la santé humaine destinées au grand public, aux chercheurs et aux professionnels de la santé- en second lieu, autour d’ateliers dans des établissements d’enseignement et de santé pour permettre une sensibilisation aux dangers et bienfaits du son sur la santé et aux métiers du son– en dernier lieu, autour d’un numéro spécial sur le Son dans le journal transdisciplinaire JIMIS.

La semaine du Son de l'UNESCO - Nice

Workshop "Sound, Neuroscience & Cognition"
Auditorium Hôpital LENVAL NICE

Fondation Lenval - Hôpital pour enfants

CONFERENCES14h - Aziz El AMRAOUI, Hearing Institute and Pasteur Institute, Paris.Progressive Sensory Disorders Team."Late-onset and progressive hearing and balance impairments: disease mechanisms and therapeutic options."Abstract: https://univ-cotedazur.fr/medias/fichier/abstract-aziz-el-amraoui_1639748606414-pdf 15h - Saaid SAFIEDDINE, Hearing Institute and Pasteur Institute, Paris.Technology and Gene Therapy for Deafness Team."Targeted deletion and in vivo rescue uncover critical roles of the neuronal t-SNARE SNAP-25 in hearing function."Abstract: https://univ-cotedazur.fr/medias/fichier/abstract-saaid-safieddine_1641488623927-pdf16h - Frank DUFOUR, EUR HEALTHY, Université Côte d'Azur,"Noise &amp; World : Exploration of the poetic and cognitive richness of noise"Abstract: https://univ-cotedazur.fr/medias/fichier/abstract-franck-dufour_1639748361827-pdf

CONCERT17h - Dr Sebastien DELHAYE / ZANNALEE Singer Composer Performer and Researcher IPMC Université Côte d'Azur, Pop Rock Repertoire. ZANNALEE is a young singer/guitarist and composer from Nice. Winner of the “Emergenza” final in Nice as a group, he performs in many bars and events on the French Riviera. His funk rock universe is influenced by PRINCE, David BOWIE and QUEEN.Chanteur Compositeur Interprète et chercheur IPMC Université Côte d'Azur, Répertoire Pop Rock. ZANNALEE est un jeune chanteur/guitariste et compositeur niçois. Gagnant de la finale niçoise "Emergenza" en groupe, il se produit dans de nombreux bars et événements de la Côte d’Azur. Son univers funk rock est influencé par PRINCE, David BOWIE et QUEEN.
About Sebastien DELHAYE / ZANNALEE: https://www.youtube.com/channel/UCFrTV91_C8_k0xiHEnN2Gxw

More details on the Scientific Workshop "Sound, Neuroscience &amp; Cogniton" here: https://univ-cotedazur.fr/recherche-innovation/structures-de-recherche/academies-dexcellence/academie-4/scientific-workshop-sound-neuroscience-cognition-lenval-nice14hLate-onset and progressive hearing and balance impairments: disease mechanisms and therapeutic optionsAziz El-AMRAOUI, PhD , Institut Pasteur, Institut de l’Audition, PARISAbstract: Progressive hearing impairment, the most frequent sensory deficit, causes communication difficulties, often associated with social isolation, depression and reduced physical and cognitive function, with a dramatic economic impact on healthcare systems worldwide. According to World Health Organization estimates, approximately 466 million people — 5% of the world's population — have a disabling hearing impairment, and this number will have increased to more than one billion by 2050. Whether of genetic origin or due to aging and/or environment, the hearing loss can affect people of any age and manifest in various forms that range from mild hearing impairment to severe and profound deafness, with or without balance deficit. So far, tremendous progress has been made regarding the mechanisms of congenital and early hearing loss, but we know very little about the key hearing pathways critical in late-onset, progressive hearing impairments, with and without balance deficits. Our recent work on two tetraspan-like proteins, member of the clarin family, highlights the key role of calrin-1 and clarin-2 in the inner ear, with defects of either clarin leading to hearing impairment, sometimes associated with variable balance and vision deficits, in mouse and humans. Using these mutant deaf mice as model systems for late-onset hearing loss, we set interdisciplinary and multi-scale approaches that allow us to study inner ear disorders, from disease mechanisms to therapy. Owing to the properties of the deafness genes’ encoded proteins, their molecular network, and characterization of related animal models, our work help: 1-	Determine where, when and how inner ear abnormalities manifest in the available defective mice to elucidate the precise molecular and cellular mechanisms underlying the hearing and balance sensory deficits (disease signature).2-	Decipher if (&amp; how) external factors, notably exposure to intense sound, impacts the onset, progression and/or severity of the disease.3)- Evaluate gene therapy interventions aimed to restore normal sensory modalities in the appropriate disease animal models.15hTargeted deletion and in vivo rescue uncover critical roles of the neuronal t-SNARE SNAP-25 in hearing functionSaaid SAFIEDDINE, PhD, Institut Pasteur, Institut de l’Audition, PARISAbstract: Phe auditory sensory inner hair cells (IHCs) encode sound into nerve impulses with high temporal precision and sensitivity over a wide range of stimulus intensities . A striking structural and functional feature of IHC synapses is the presence of an electron-dense presynaptic organelle of submicron diameter called a ribbon, marking the centre of the synaptic active zone. Despite their structural differences, IHC ribbon synapses and conventional central nervous system (CNS) synapses share several key mechanisms of regulated synaptic vesicle exocytosis. IHC and CNS synapses are both equipped with the presynaptic scaffold proteins, bassoon and RIM. The presence of the neuronal SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) complex in auditory hair cell is well documented, including syntaxin 1, SNAP25 and synaptobrevin1/2.These observations led to the notion that vesicle fusion at both synapses involves similar SNARE proteins. However, the study of null mutant mouse models failed to reveal functional role for the neuronal SNARE proteins in IHC synaptic transmission. This finding led to the proposal that IHC synapse operate without neuronal SNARE. It worthy to note that the null mutant mouse models for many of the neuronal SNARE proteins, die at birth or shortly after. Therefore, the IHC function in these mutants could only be analysed in organotypic culture, wherein the findings may not reproduce the functioning of IHC synapse in a healthy and mature hearing organ. To untangle this issue, we focused on SNAP-25, a key component of the canonical synaptic SNARE complex. We generated a hair cell-specific Snap-25 knockout (Snap-25 cKO) mouse model allowing to study the effect of acute inactivation of Snap-25 in IHCs at both neonatal and mature stages. We found that the mice subjected to Snap-25 inactivation at mature stage, i.e., after the hearing onset, developed a severe to profound deafness which was associated with a defective exocytosis at IHC synapses followed by ribbon degeneration and a progressive loss of hair cells. Viral mediated transfer of SNAP25 cDNA rescued all these phenotype aspects. These results demonstrated that SNAP-25 is essential for normal hearing function by ensuring the rapid fusion of vesicles at the IHC ribbon synapse and strongly suggest that this fusion is governed by the canonical neuronal SNARE complex16hNoise &amp; World: 
Exploring the Poetic and Cognitive Richness of Noise

Frank DUFOUR, EUR HEALTHY, Université Côte d'Azur

Abstract:
 The goal of this workshop is to present noise as the central theme of a multimodal ecology of perception. Through the presentation of various examples borrowed from the domains of artistic expression, psychology of perception and urban design, the workshop will allow participants to understand some of the positive contributions of noise in human communications, and interactions with natural as well as technological environments. This workshop wishes to invite participants to consider noise beyond the traditional and paradoxical attitude that is frantically attempting to limit noise all the while contributing to its inflation, and to further engage in an ecological reflection upon this highly meaningful component of our environments.

Remote connection to the workshop here : https://univ-cotedazur.zoom.us/s/87408091472The whole Week of Sound UNESCO NICE 2022 here / Toute la Semaine su Son de l&#x27;UNESCO 2022 à NICE ici : https://cutt.ly/VYGStuv

SDSU2022NICE - Scientific Workshop "Sound, Neuroscience & Cognition"

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