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IDDI SYMPOSIUM - Are Randomized Clinical Trials Obsolete?

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Auditorium Royal Museum of Fine Arts of Belgium

Rue du Musée, 9

1000 Bruxelles

Belgium

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Event description
This symposium will address the sources of bias that continue to threaten sound clinical research now and in the foreseeable future.

About this Event

OUTLINE:

April 2020 will mark the 40th anniversary of Jay Herson’s paper “Patient Registration in a Cooperative Oncology Group”. That paper, published in the first volume of the journal Controlled Clinical Trials, dealt with sources of bias and randomization practices that existed at the time. Looking back, it is surprising to see how much has changed since 1980. Whilst randomization remains a key design feature for confirmatory trials aimed at new drug approval, many innovative non-randomized study designs have been proposed and used in recent years.

This symposium will address the sources of bias that continue to threaten sound clinical research now and in the foreseeable future. Past achievements and the current landscape will be described along with realistic proposals to move the field forward. Read Symposium outline here.

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AGENDA

09:00 - 09:30 – Welcome and Registration

09:30 – 09:45 – Opening remarks – Marc Buyse, IDDI and U Hasselt, Belgium

Session 1 Laurence Collette, EORTC, Belgium, Moderator

09:45 – 10:20 – KEYNOTE TALK 1: Bias and randomization: 1980 – 2020 – 2060 – Jay Herson, Johns Hopkins U, Baltimore, MD, USA

10:20 – 10:45 – Innovative trial designs with and without randomization – François Beckers, Merck, Germany

10:45 – 11:15 – Coffee break

11:15 – 11:40 – Does precision medicine need randomized trials? – Everardo Saad, IDDI, Belgium

11:40 – 12:05 – Can causal inference ever replace randomization? – Johan Steen, U Ghent, Belgium

12:05 – 12:30 – Q & A and discussion – Moderator and panelists

12:30 – 13:45 – Lunch break

Session 2 Catherine Legrand, UCLouvain, Belgium, Moderator

13:45 – 14:20 – KEYNOTE TALK 2: SOCRATES and the need for big randomized data – John Simes, NHMRC Clinical Trials Centre, Sydney, Australia

14:20 – 14:45 – Pragmatic randomized trials – Frank Hulstaert, KCE, Belgium

14:45 – 15:15 – Coffee break

Session 3 Bart Spiessens, Janssen R&D, Belgium, Moderator

15:15 – 15:50 – KEYNOTE TALK 3: Real-world evidence in medicines development and regulatory affairs: Applications and future directions – John O’Donnell, Bristol-Myers Squibb, Princeton, NJ, USA

15:50 – 16:15 – The promise and perils of real-world evidence and big data – Tomasz Burzykowski, IDDI and U Hasselt, Belgium

16:15 – 16:40 – Q & A and discussion – Moderators and panelists

17:00 – 19:00 – Networking Reception

We look forward to welcoming you!

The IDDI Team

Date and Time

Location

Auditorium Royal Museum of Fine Arts of Belgium

Rue du Musée, 9

1000 Bruxelles

Belgium

View Map

Refund Policy

No Refunds

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